Best Bug Sprays to Kill Spiders: Top Plant-Based and Conventional Picks

Protect indoor and outdoor spaces from spiders and other common pests with effective, safe options. This guide highlights five top picks, spanning plant-based peppermint formulas to traditional chemical sprays. Each product section includes key features, use cases, and practical application tips to help you choose the right solution for your home.

Product Brand Size Type
Mighty Mint Peppermint Oil Insect Repellent Spray Mighty Mint 16 oz Plant-based
Mighty Mint Gallon Insect & Pest Repellent Mighty Mint 128 oz Plant-based
STEM Kills Ants, Roaches And Spiders STEM 10 fl oz Botanical
Spectracide Bug Stop Home Barrier Spray Spectracide 1.33 gal Chemical/Contact
Ortho BugClear Insect Killer Ortho 32 oz Chemical/Outdoor

Mighty Mint Peppermint Oil Insect Repellent Spray

Mighty Mint Peppermint Oil Insect Repellent Spray

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The Mighty Mint Peppermint Oil Insect Repellent Spray provides a plant-based defense against spiders, ants, roaches, and more. Formulated with extra-concentrated peppermint oil, it offers a powerful deterrent while remaining pet-friendly and family-safe when used as directed. Suitable for both indoor and outdoor use, it can be applied along baseboards, entryways, patios, and other high-traffic areas to discourage insects from entering living spaces.

Key features include a natural scent, no harsh fumes, and surfaces that remain undamaged when applied as directed. This option is ideal for households seeking a non-toxic approach to spider and pest control without sacrificing effectiveness.

Mighty Mint Gallon (128 oz) Insect and Pest Repellent

Mighty Mint Gallon Insect and Pest Repellent

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This gallon-size Mighty Mint option offers the same pet-friendly, plant-based peppermint protection in a larger package, delivering economical coverage for bigger homes or outdoor spaces. It is designed for both interior and exterior use, providing a versatile defense against spiders, ants, roaches, and more while avoiding harsh chemical odors and residues when used as directed.

Ideal for homeowners who want a long-lasting mint-based repellent that can be applied to entry points, patios, and perimeters to reduce pest intrusion and spider activity around living areas.

STEM Kills Ants, Roaches And Spiders

STEM Botanical Bug Spray

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STEM’s plant-based bug spray targets ants, roaches, and spiders with an insect-control formula derived from botanical extracts. It is designed for use around people and pets when used as directed, offering an entomologist-tested solution with a fresh scent and no added dyes or harsh chemical odors. This makes it suitable for households seeking a natural alternative that still delivers quick knockdown of pests.

The product emphasizes safety alongside efficacy, making it a practical option for occasional indoor and outdoor spot treatments, especially in kitchens, bathrooms, and entryways susceptible to spider and insect activity.

Spectracide Bug Stop Home Barrier Spray

Spectracide Bug Stop Home Barrier Spray

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Spectracide Bug Stop Home Barrier Spray creates a home barrier against a broad range of insects. It is designed for both indoor and outdoor use and can be refilled with the optional AccuShot power sprayer. The product claims on-contact kill and extended residual control, offering up to 12 months of protection on non-porous surfaces against cockroaches, ants, and spiders. This makes it a reliable, perimeter-focused option for larger properties and perimeter treatment around foundations, patios, and garages.

Users should follow label directions for safe application around kids and pets, and consider surface compatibility before treating porous materials or fabrics.

Ortho BugClear Insect Killer For Lawns And Landscapes

Ortho BugClear Insect Killer

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Ortho BugClear is designed for outdoor use across lawns and landscapes. It claims rapid action against a broad list of pests—including spiders, ants, mosquitoes, fleas, and more—providing long-lasting control around the home perimeter and on ornamental plants. This product is well-suited for exterior applications where a strong, fast-acting spray is desired to create a pest-reduced zone around outdoor living spaces.

As with any outdoor spray, follow label directions, protect beneficial insects where possible, and avoid drifting onto non-target plants or waterways during application.

Buying Guide: Key Purchase Considerations

When choosing a bug spray to kill spiders, buyers should consider pest type, application area, safety, and environmental impact. Plant-based formulas, like Mighty Mint and STEM, emphasize natural ingredients, pet safety, and reduced chemical odors, making them suitable for households seeking low-toxicity options. For larger spaces or perimeters, concentrates and gallon-size options offer cost efficiency and extended coverage, as seen with Mighty Mint Gallon and Spectracide barrier sprays.

Thermal or mechanical factors, such as the method of delivery (trigger spray vs. continuous power sprayer), influence ease of use and effectiveness. Spectracide’s refillable system and Ortho’s lawn-and-landscapes approach target outdoor settings, while interior-focused sprays emphasize surface compatibility and minimal staining. Consider surface materials, presence of pets or children, and proximity to food prep areas when selecting a product.

Effect duration varies by formula and environment. Contact-kill sprays provide quick knockdown, while residual-action products help deter re-entry over time. For spider-specific control, look for products labeled as effective against spiders in addition to common pests. Always follow label directions, test on a small inconspicuous area if concerned about surfaces, and practice safe storage away from children and pets.